Author Tzvetkov, Mladen Vassilev

• 2021 | Journal Article | Research Paper | 
  ​ ​Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients​
  Steimer, W.; Pischa, K.; Leucht, S.; Kullmann, M.; Ouethy, T.; Rafehi, M.   & Matthaei, J. et al.​ (2021) 
  Frontiers in Pharmacology, 12.​ DOI: https://doi.org/10.3389/fphar.2021.688950 
  ​Details  DOI 

• 2017 | Journal Article
  ​ ​Tropane alkaloids as substrates and inhibitors of human organic cation transporters of the SLC22 (OCT) and the SLC47 (MATE) families (vol 398, pg 237, 2017)​
  Chen, J.; Brockmoeller, J.; Seitz, T.; Koenig, J.; Tzvetkov, M. V. & Chen, X.​ (2017) 
  Biological Chemistry, 398(7).​ DOI: https://doi.org/10.1515/hsz-2017-0129 
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• 2017 | Journal Article
  ​ ​Tropane alkaloids as substrates and inhibitors of human organic cation transporters of the SLC22 (OCT) and the SLC47 (MATE) families​
  Chen, J.; Brockmoeller, J.; Seitz, T.; Koenig, J.; Tzvetkov, M. V. & Chen, X.​ (2017) 
  Biological Chemistry, 398(2) pp. 237​-249​.​ DOI: https://doi.org/10.1515/hsz-2016-0236 
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• 2016 | Journal Article
  ​ ​Loss-of-function polymorphisms in the organic cation transporter OCT1 are associated with reduced postoperative tramadol consumption​
  Stamer, U. M.; Frank, M.; Stüber, F.; Brockmöller, J. ; Steffens, M. & Tzvetkov, M. V.​ (2016) 
  Pain, 157(11) pp. 2467​-2475​.​ DOI: https://doi.org/10.1097/j.pain.0000000000000662 
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• 2016 | Journal Article
  ​ ​OCT1 Mediates Hepatic Uptake of Sumatriptan and Loss-of-Function OCT1 Polymorphisms Affect Sumatriptan Pharmacokinetics​
  Matthaei, J.; Kuron, D.; Faltraco, F.; Knoch, T.; Pereira, J. N. D. S.; Abu Abed, M. & Prukop, T. et al.​ (2016) 
  Clinical Pharmacology & Therapeutics, 99(6) pp. 633​-641​.​ DOI: https://doi.org/10.1002/cpt.317 
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• 2016 | Journal Article | 
  ​ ​Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters​
  Matthaei, J.; Tzvetkov, M. V.; Gal, V.; Sachse-Seeboth, C.; Sehrt, D.; Hjelmborg, J. B. & Hofmann, U. et al.​ (2016) 
  Genome Medicine, 8 art. 119​.​ DOI: https://doi.org/10.1186/s13073-016-0372-2 
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• 2015 | Conference Abstract
  ​ ​OCT1 is the clinically relevant hepatic transporter of sumatriptan: in vitro and in vivo evidences​
  Kuron, D.; Matthaei, J.; Brockmoeller, J. & Tzvetkov, M. V.​ (2015)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 388 ​81st Annual Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie-e-V​, Kiel, GERMANY.
  New york​: Springer.
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• 2015 | Conference Abstract
  ​ ​Functional characterization of the genetic polymorphisms in the OCT1 promoter​
  Bokelmann, K.; Brockmoeller, J. & Tzvetkov, M. V.​ (2015)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 388 , Kiel, GERMANY.
  New york​: Springer.
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• 2015 | Conference Abstract
  ​ ​Alkaloids as substrates and inhibitors of organic cation transporters​
  Chen, J.; Brockmoeller, J.; Chen, X. & Tzvetkov, M. V.​ (2015)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 388 ​81st Annual Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie-e-V​, Kiel, GERMANY.
  New york​: Springer.
  ​Details  WoS 

• 2015 | Conference Abstract
  ​ ​Does the apparently predictive haplotype Met408-Del420 really exist and how strong it affects OCT1 activity?​
  Seitz, T.; Bokelmann, K.; Pereira, J. N. dos S.; Mueller, T.; Brockmoeller, J.; Koepsell, H. & Tzvetkov, M. V.​ (2015)
  Naunyn-Schmiedeberg s Archives of Pharmacology, 388 ​81st Annual Meeting of the Deutsche-Gesellschaft-fur-Experimentelle-und-Klinische-Pharmakologie-und Toxikologie-e-V​, Kiel, GERMANY.
  New york​: Springer.
  ​Details  WoS 

• 2015 | Journal Article
  ​ ​Impact of mineralocorticoid receptor polymorphisms on urinary electrolyte excretion with and without diuretic drugs​
  Dalila, N.; Brockmoeller, J.; Tzvetkov, M. V.; Schirmer, M.; Haubrock, M.   & Vormfelde, S. V.​ (2015) 
  Pharmacogenomics, 16(2) pp. 115​-127​.​ DOI: https://doi.org/10.2217/pgs.14.163 
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• 2015 | Journal Article
  ​ ​High-throughput screening identified inherited genetic variations in the EGFR pathway contributing to skin toxicity of EGFR inhibitors​
  Hasheminasab, S.-M.; Tzvetkov, M. V.; Schumann, C.; Ruediger, S.; Boeck, S.; Heinemann, V. & Kaechele, V. et al.​ (2015) 
  Pharmacogenomics, 16(14) pp. 1605​-1619​.​ DOI: https://doi.org/10.2217/pgs.15.97 
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• 2015 | Journal Article | 
  ​ ​Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1​
  Seitz, T.; Stalmann, R.; Dalila, N.; Chen, J. ; Pojar, S.; Pereira, J. N. dos S. & Kraetzner, R. et al.​ (2015) 
  Genome Medicine, 7 art. 56​.​ DOI: https://doi.org/10.1186/s13073-015-0172-0 
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• 2014 | Journal Article
  ​ ​The Poorly Membrane Permeable Antipsychotic Drugs Amisulpride and Sulpiride Are Substrates of the Organic Cation Transporters from the SLC22 Family​
  Pereira, J. N. dos S.; Tadjerpisheh, S.; Abu Abed, M.; Saadatmand, A. R.; Weksler, B.; Romero, I. A. & Couraud, P.-O. et al.​ (2014) 
  The AAPS Journal, 16(6) pp. 1247​-1258​.​ DOI: https://doi.org/10.1208/s12248-014-9649-9 
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• 2014 | Journal Article
  ​ ​Genetic Polymorphisms in 11 beta-Hydroxysteroid Dehydrogenase Type 1 Correlate With the Postdexamethasone Cortisol Levels and Bone Mineral Density in Patients Evaluated for Osteoporosis​
  Siggelkow, H.; Etmanski, M.; Bozkurt, S.; Gross, P.; Koepp, R.; Brockmoeller, J. & Tzvetkov, M. V.​ (2014) 
  The Journal of Clinical Endocrinology & Metabolism, 99(2) pp. E293​-E302​.​ DOI: https://doi.org/10.1210/jc.2013-1418 
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• 2014 | Journal Article | Letter Note
  ​ ​Does the haplotype Met408-Del420, which was apparently predictive for imatinib efficacy, really exist and how strongly may it affect OCT1 activity?​
  Tzvetkov, M. V.; Seitz, T. ; Bokelmann, K.; Mueller, T.; Brockmoeller, J. & Koepsell, H.​ (2014) 
  Blood, 123(9) pp. 1427​-1429​.​ DOI: https://doi.org/10.1182/blood-2013-11-535864 
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• 2014 | Journal Article
  ​ ​PharmGKB summary: tramadol pathway​
  Gong, L. I.; Stamer, U. M.; Tzvetkov, M. V.; Altman, R. B. & Klein, T. E.​ (2014) 
  Pharmacogenetics and Genomics, 24(7) pp. 374​-380​.​ DOI: https://doi.org/10.1097/FPC.0000000000000057 
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• 2013 | Conference Abstract
  ​ ​Functional and molecular genetic analyses of 9 newly identified XPD-deficient patients reveal a novel mutation resulting in TTD as well as in XP/CS complex phenotypes​
  Emmert, S.; Schaefer, A.; Gratchev, A.; Seebode, C.; Hofmann, L.; Schubert, S. & Laspe, P. et al.​ (2013)
  JDDG Journal der Deutschen Dermatologischen Gesellschaft, 11(9) 
  Hoboken​: Wiley-blackwell.
  ​Details  WoS 

• 2013 | Conference Abstract
  ​ ​Functional molecular-genetic analysis of 16 XP-C patients from Germany: environmental factors predominately contribute to phenotype variations​
  Schaefer, A.; Hofmann, L.; Gratchev, A.; Laspe, P.; Schubert, S.; Schuerer, A. & Ohlenbusch, A. et al.​ (2013)
  Experimental Dermatology, 22(3) pp. E21​-E22. ​40th Annual Meeting of the Association-of-Dermatological-Research​, Dessau, GERMANY.
  Hoboken​: Wiley-blackwell.
  ​Details  WoS 

• 2013 | Journal Article | 
  ​ ​Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration​
  Tzvetkov, M. V.; Pereira, J. N. dos S.; Meineke, I.; Saadatmand, A. R.; Stingl, J. C. & Brockmoeller, J.​ (2013) 
  Biochemical Pharmacology, 86(5) pp. 666​-678​.​ DOI: https://doi.org/10.1016/j.bcp.2013.06.019 
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